KMID : 1007520110200030845
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Food Science and Biotechnology 2011 Volume.20 No. 3 p.845 ~ p.850
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Neuronal Cell Protective Effect of Aerial Parts of Chinese Lizard¡¯s Tail (Saururus chinensis (Lour.) Baill.)
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Jeong Hee-Rok
Jeong Chang-Ho Kwak Ji-Hyun Kim Ji-Hye Lee Uk Choi Gwi-Nam Choi Sung-Gil Heo Ho-Jin
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Abstract
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The antioxidant and neuronal cell protective effects of silica-gel open column chromatographic fractions, obtained from Chinese lizard¡¯s tail (Saururus chinensis) methanolic extract, were investigated. The ABTS radical scavenging and ferric reducing antioxidant power (FRAP) assays indicated that the SC4 fraction (eluted with chloroform/methanol by 4:1, v/v) obtained from Chinese lizard¡¯s tail was more potent radical scavengers and reducing agents than that of other 5 fractions. The SC4 fraction also presented protective effects against H2O2- induced neurotoxicity in a dose-dependent manner. Therefore, our study suggested that the SC4 fraction has strong antioxidant and neuronal protective effects which are correlated with its high level of phenolics, particularly quercitrin and quercetin.
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KEYWORD
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Chinese lizard¡¯s tail (Saururus chinensis (Lour.) Baill.), quercitrin, quercetin, antioxidant, neuronal protective effect
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